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Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

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Schäfer, Nicole ; Wolf, Hannah N. ; Enzbrenner, Anne ; Schikora, Juliane ; Reichenthaler, Maria ; Enzmann, Volker ; Pauly, Diana
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2021 15:11


The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD). The AMD pathogenesis includes both increased oxidative stress and complement dysregulation. Physiological sources of oxidative stress in the retina are well known, ...


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