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SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line

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Stöckl, Sabine ; Lindner, Georg ; Li, Shushan ; Schuster, Philipp ; Haferkamp, Sebastian ; Wagner, Ferdinand ; Prodinger, Peter M. ; Multhoff, Gabriele ; Boxberg, Melanie ; Hillmann, Axel ; Bauer, Richard J. ; Grässel, Susanne
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Date of publication of this fulltext: 13 Jan 2021 11:04


As most chemotherapeutic drugs are ineffective in the treatment of chondrosarcoma, we studied the expression pattern and function of SOX9, the master transcription factor for chondrogenesis, in chondrosarcoma, to understand the basic molecular principles needed for engineering new targeted therapies. Our study shows an increase in SOX9 expression in chondrosarcoma compared to normal cartilage, ...


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