B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats

URN to cite this document:: urn:nbn:de:bvb:355-epub-442094
DOI to cite this document:: 10.5283/epub.44209

Steines, Louisa

; Poth, Helen ; Herrmann, Marlene ; Schuster, Antonia ; Banas, Bernhard

; Bergler, Tobias

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Date of publication of this fulltext: 13 Jan 2021 14:40

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Abstract

Intra-renal tertiary lymphoid organs (TLOs) are associated with worsened outcome in kidney transplantation (Ktx). We used an anti-BAFF (B cell activating factor) intervention to investigate whether BAFF is required for TLO formation in a full MHC-mismatch Ktx model in rats. Rats received either therapeutic immunosuppression (no rejection, NR) or subtherapeutic immunosuppression (chronic ...