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PD-L1 Influences Cell Spreading, Migration and Invasion in Head and Neck Cancer Cells

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Eichberger, Jonas ; Schulz, Daniela ; Pscheidl, Kristian ; Fiedler, Mathias ; Reichert, Torsten Eugen ; Bauer, Richard Josef ; Ettl, Tobias
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Jan 2021 14:53


The programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) axis blockade has been implemented in advanced-stage tumor therapy for various entities, including head and neck squamous cell carcinoma (HNSCC). Despite a promising tumor response in a subgroup of HNSCC patients, the majority suffer from disease progression. PD-L1 is known to influence several intrinsic mechanisms ...


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