PD-L1 Influences Cell Spreading, Migration and Invasion in Head and Neck Cancer Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-442102
DOI to cite this document:: 10.5283/epub.44210

Eichberger, Jonas ; Schulz, Daniela

; Pscheidl, Kristian ; Fiedler, Mathias ; Reichert, Torsten E. ; Bauer, Richard J.

; Ettl, Tobias

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Date of publication of this fulltext: 13 Jan 2021 14:53

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Abstract

The programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) axis blockade has been implemented in advanced-stage tumor therapy for various entities, including head and neck squamous cell carcinoma (HNSCC). Despite a promising tumor response in a subgroup of HNSCC patients, the majority suffer from disease progression. PD-L1 is known to influence several intrinsic mechanisms ...