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Cell-Type-Specific Complement Profiling in the ABCA4−/− Mouse Model of Stargardt Disease

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Jabri, Yassin ; Biber, Josef ; Diaz-Lezama, Nundehui ; Grosche, Antje ; Pauly, Diana
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Jan 2021 15:10


Stargardt macular degeneration is an inherited retinal disease caused by mutations in the ATP-binding cassette subfamily A member 4 (ABCA4) gene. Here, we characterized the complement expression profile in ABCA4(-/-) retinae and aligned these findings with morphological markers of retinal degeneration. We found an enhanced retinal pigment epithelium (RPE) autofluorescence, cell loss in the inner ...


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