A novel mouse model of obstructive sleep apnea by bulking agent-induced tongue enlargement results in left ventricular contractile dysfunction

URN to cite this document:: urn:nbn:de:bvb:355-epub-442445
DOI to cite this document:: 10.5283/epub.44244

Lebek, Simon ; Hegner, Philipp ; Schach, Christian ; Reuthner, Katrin ; Tafelmeier, Maria

; Maier, Lars S. ; Arzt, Michael ; Wagner, Stefan

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Date of publication of this fulltext: 15 Mar 2021 11:57

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Item type:	Article
Open Access Type:	Gold (with APC)
Journal or Publication Title:	PLoS One
Publisher:	PLOS
Volume:	15
Number of Issue or Book Chapter:	12
Page Range:	e0243844
Date:	10 December 2020
Institutions:	Medicine > Lehrstuhl für Innere Medizin II
Projects (Historical):	Open Access Publizieren (DFG)
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	In Press
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	44244

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Abstract

Aims Obstructive sleep apnea (OSA) is a widespread disease with high global socio-economic impact. However, detailed pathomechanisms are still unclear, partly because current animal models of OSA do not simulate spontaneous airway obstruction. We tested whether polytetrafluoroethylene (PTFE) injection into the tongue induces spontaneous obstructive apneas. Methods and results PTFE (100 μl) ...