Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine

URN to cite this document:: urn:nbn:de:bvb:355-epub-442481
DOI to cite this document:: 10.5283/epub.44248

Lage-Rupprecht, Vanessa ; Zhou, Li ; Bianchini, Gaia ; Aghvami, S. Sara ; Mueller, Max ; Rózsa, Balázs ; Sassoè-Pognetto, Marco ; Egger, Veronica

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Date of publication of this fulltext: 13 Jan 2021 15:26

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Abstract

In the rodent olfactory bulb the smooth dendrites of the principal glutamatergic mitral cells (MCs) form reciprocal dendrodendritic synapses with large spines on GABAergic granule cells (GC), where unitary release of glutamate can trigger postsynaptic local activation of voltage-gated Na+-channels (Navs), that is a spine spike. Can such single MC input evoke reciprocal release? We find that ...