Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial

URN to cite this document:: urn:nbn:de:bvb:355-epub-443760
DOI to cite this document:: 10.5283/epub.44376

Simon, Philipp ; Petroff, David ; Busse, David

; Heyne, Jana ; Girrbach, Felix ; Dietrich, Arne ; Kratzer, Alexander Ludwig ; Zeitlinger, Markus ; Kloft, Charlotte ; Kees, Frieder ; Wrigge, Hermann ; Dorn, Christoph

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Date of publication of this fulltext: 11 Jan 2021 05:57

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Abstract

Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index (BMI) >= 35 kg/m(2)) and age-/sex-matched nonobese (18.5 kg/m(2) >= BMI <= 30 kg/m(2)) surgical patients received a short-term infusion of 1000-mg meropenem. Concentrations were determined via high performance liquid ...