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Gene Expression Signatures of a Preclinical Mouse Model during Colorectal Cancer Progression under Low-Dose Metronomic Chemotherapy

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Ho-Xuan, Hung ; Lehmann, Gerhard ; Glazar, Petar ; Gypas, Foivos ; Eichner, Norbert ; Heizler, Kevin ; Schlitt, Hans J. ; Zavolan, Mihaela ; Rajewsky, Nikolaus ; Meister, Gunter ; Hackl, Christina
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 08 Jan 2021 17:14


Simple Summary: Colorectal cancer is one of the most frequent types of cancer world-wide, leading to over 500,000 cancer-related deaths each year. Although many primary colorectal cancer patients can be cured by surgery, up to 60% will develop metastases. Chemotherapeutic strategies are well-established, but finally often lead to chemo-resistance and tumor relapse. A specific chemotherapeutic ...


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