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High‐Pressure‐Mediated Thiourea‐Organocatalyzed Asymmetric Michael Addition to (Hetero)aromatic Nitroolefins: Prediction of Reaction Parameters by PCP‐SAFT Modelling

URN to cite this document:
urn:nbn:de:bvb:355-epub-444658
DOI to cite this document:
10.5283/epub.44465
Weinbender, Thomas ; Knierbein, Michael ; Bittorf, Lukas ; Reiser, Oliver ; ; ; ;
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Date of publication of this fulltext: 20 Jan 2021 12:44


Abstract

Thiourea-organocatalyzed Michael additions of diethyl malonate to various heteroaromatic nitroolefins (13 examples) have been studied under high-pressure (up to 800 MPa) and ambient pressure conditions. High pressure was conducive to enhanced product yields by a factor of 2-12 at a given reaction time, high reaction rates (reaction times were decreased from 72-24 h down to 4-24 h) and high ...

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