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CopR, a Global Regulator of Transcription to Maintain Copper Homeostasis in Pyrococcus furiosus

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Grünberger, Felix ; Reichelt, Robert ; Waege, Ingrid ; Ned, Verena ; Bronner, Korbinian ; Kaljanac, Marcell ; Weber, Nina ; El Ahmad, Zubeir ; Knauss, Lena ; Madej, M. Gregor ; Ziegler, Christine ; Grohmann, Dina ; Hausner, Winfried
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jan 2021 15:15


Although copper is in many cases an essential micronutrient for cellular life, higher concentrations are toxic. Therefore, all living cells have developed strategies to maintain copper homeostasis. In this manuscript, we have analyzed the transcriptome-wide response of Pyrococcus furiosus to increased copper concentrations and described the essential role of the putative copper-sensing ...


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