CopR, a Global Regulator of Transcription to Maintain Copper Homeostasis in Pyrococcus furiosus

URN to cite this document:: urn:nbn:de:bvb:355-epub-444855
DOI to cite this document:: 10.5283/epub.44485

Grünberger, Felix ; Reichelt, Robert ; Waege, Ingrid ; Ned, Verena ; Bronner, Korbinian ; Kaljanac, Marcell ; Weber, Nina ; El Ahmad, Zubeir ; Knauss, Lena ; Madej, M. Gregor

; Ziegler, Christine ; Grohmann, Dina ; Hausner, Winfried

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Date of publication of this fulltext: 20 Jan 2021 15:15

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Abstract

Although copper is in many cases an essential micronutrient for cellular life, higher concentrations are toxic. Therefore, all living cells have developed strategies to maintain copper homeostasis. In this manuscript, we have analyzed the transcriptome-wide response of Pyrococcus furiosus to increased copper concentrations and described the essential role of the putative copper-sensing ...