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siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects

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Meister, Gunter ; Neumeier, Julia
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Mar 2021 12:30


Short interfering RNAs (siRNAs) are processed from long double-stranded RNA (dsRNA), and a guide strand is selected and incorporated into the RNA-induced silencing complex (RISC). Within RISC, a member of the Argonaute protein family directly binds the guide strand and the siRNA guides RISC to fully complementary sites on-target RNAs, which are then sequence-specifically cleaved by the Argonaute ...


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