Go to content
UR Home

siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects

URN to cite this document:
urn:nbn:de:bvb:355-epub-444873
DOI to cite this document:
10.5283/epub.44487
Meister, Gunter ; Neumeier, Julia
[img]
Preview
License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)
Date of publication of this fulltext: 15 Mar 2021 12:30


Abstract

Short interfering RNAs (siRNAs) are processed from long double-stranded RNA (dsRNA), and a guide strand is selected and incorporated into the RNA-induced silencing complex (RISC). Within RISC, a member of the Argonaute protein family directly binds the guide strand and the siRNA guides RISC to fully complementary sites on-target RNAs, which are then sequence-specifically cleaved by the Argonaute ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons