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Impact of salt and the osmoprotective transcription factor NFAT-5 on macrophages during mechanical strain

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Schröder, Agnes ; Leikam, Alexandra ; Käppler, Paul ; Neubert, Patrick ; Jantsch, Jonathan ; Neuhofer, Wolfgang ; Deschner, James ; Proff, Peter ; Kirschneck, Christian
Date of publication of this fulltext: 26 Jan 2021 16:29

This publication is part of the DEAL contract with Wiley.


Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells-5 (NFAT-5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory immunological process, we investigated the influence of NaCl and NFAT-5 on the expression pattern of macrophages in a model of simulated OTM. RAW264.7 ...


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