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Impact of salt and the osmoprotective transcription factor NFAT-5 on macrophages during mechanical strain

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Schröder, Agnes ; Leikam, Alexandra ; Käppler, Paul ; Neubert, Patrick ; Jantsch, Jonathan ; Neuhofer, Wolfgang ; Deschner, James ; Proff, Peter ; Kirschneck, Christian
Date of publication of this fulltext: 26 Jan 2021 16:29


Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells-5 (NFAT-5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory immunological process, we investigated the influence of NaCl and NFAT-5 on the expression pattern of macrophages in a model of simulated OTM. RAW264.7 macrophages ...


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