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Hypertonicity counteracts MCL 1 and renders BCL XL a synthetic lethal target in head and neck cancer

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Ehrenschwender, Martin ; Heimer, Sina ; Knoll, Gertrud ; Neubert, Patrick ; Hammer, Karin P. ; Wagner, Stefan ; Bauer, Richard J. ; Jantsch, Jonathan
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 26 Jan 2021 16:42

This publication is part of the DEAL contract with Wiley.


Head and neck squamous cell carcinoma (HNSCC) is an aggressive and difficult-to-treat cancer entity. Current therapies ultimately aim to activate the mitochondria-controlled (intrinsic) apoptosis pathway, but complex alterations in intracellular signaling cascades and the extracellular microenvironment hamper treatment response. On the one hand, proteins of the BCL-2 family set the threshold for ...


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