Go to content
UR Home

Hypertonicity counteracts MCL 1 and renders BCL XL a synthetic lethal target in head and neck cancer

URN to cite this document:
urn:nbn:de:bvb:355-epub-445317
DOI to cite this document:
10.5283/epub.44531
Ehrenschwender, Martin ; Heimer, Sina ; Knoll, Gertrud ; Neubert, Patrick ; Hammer, Karin P. ; Wagner, Stefan ; Bauer, Richard J. ; Jantsch, Jonathan
[img]
Preview
License: Creative Commons Attribution Non-commercial 4.0
PDF - Published Version
(15MB)
Date of publication of this fulltext: 26 Jan 2021 16:42

This publication is part of the DEAL contract with Wiley.


Abstract

Head and neck squamous cell carcinoma (HNSCC) is an aggressive and difficult-to-treat cancer entity. Current therapies ultimately aim to activate the mitochondria-controlled (intrinsic) apoptosis pathway, but complex alterations in intracellular signaling cascades and the extracellular microenvironment hamper treatment response. On the one hand, proteins of the BCL-2 family set the threshold for ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons