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Hypertonicity counteracts MCL 1 and renders BCL XL a synthetic lethal target in head and neck cancer

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Ehrenschwender, Martin ; Heimer, Sina ; Knoll, Gertrud ; Neubert, Patrick ; Hammer, Karin P. ; Wagner, Stefan ; Bauer, Richard J. ; Jantsch, Jonathan
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 26 Jan 2021 16:42


Head and neck squamous cell carcinoma (HNSCC) is an aggressive and difficult‐to‐treat cancer entity. Current therapies ultimately aim to activate the mitochondria‐controlled (intrinsic) apoptosis pathway, but complex alterations in intracellular signaling cascades and the extracellular microenvironment hamper treatment response. On the one hand, proteins of the BCL‐2 family set the threshold for ...


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