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Advances in optical single-molecule detection: On the road to super-sensitive bioaffinity assays

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Farka, Zdeněk ; Mickert, Matthias J. ; Pastucha, Matěj ; Gorris, Hans H.
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 26 Jan 2021 11:12

This publication is part of the DEAL contract with Wiley.


The ability to detect low concentrations of analytes and in particular low‐abundance biomarkers is of fundamental importance, e.g., for early‐stage disease diagnosis. The prospect of reaching the ultimate limit of detection has driven the development of single‐molecule bioaffinity assays. While many review articles have highlighted the potentials of single‐molecule technologies for analytical and ...


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