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Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson’s disease: Balancing immunosuppression

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Lubnow, Matthias ; Schmidt, Barbara ; Fleck, Martin ; Salzberger, Bernd ; Müller, Thomas ; Peschel, Georg ; Schneckenpointner, Roland ; Lange, Tobias ; Hitzenbichler, Florian ; Kieninger, Martin ; Lunz, Dirk ; Graf, Bernhard ; Brochhausen, Christoph ; Weber, Florian ; Lüke, Florian ; Peterhoff, David ; Schuster, Philipp ; Hiergeist, Andreas ; Offner, Robert ; Hehr, Ute ; Wallner, Stefan ; Hanses, Frank ; Schmid, Stephan ; Weigand, Kilian ; Geismann, Florian ; Poeck, Hendrik ; Pukrop, Tobias ; Evert, Matthias ; Gessner, Andre ; Burkhardt, Ralph ; Herr, Wolfgang ; Maier, Lars S. ; Heudobler, Daniel
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Jan 2021 15:06


A 21-year-old woman was hospitalized due to coronavirus disease 2019 (COVID-19)-associated respiratory and hepatic impairment concomitant with severe hemolytic anemia. Upon diagnosis of secondary hemophagocytic lymphohistiocytosis, immunosuppression with anakinra and steroids was started, leading to a hepatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and viremia. ...


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