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Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study

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Hau, Peter ; Dirven, Linda ; Luerding, Ralf ; Beier, Dagmar ; Bumes, Elisabeth ; Reinert, Christiane ; Seidel, Clemens ; Bonsanto, Matteo Mario ; Bremer, Michael ; Rieken, Stefan ; Combs, Stephanie E. ; Herrlinger, Ulrich ; Seliger, Corinna ; Kuntze, Holger ; Mayer‑Steinacker, Regine ; Dieing, Annette ; Bartels, Claudius ; Schnell, Oliver ; Weyerbrock, Astrid ; Seidel, Sabine ; Grauer, Oliver ; Nadji‑Ohl, Minou ; Paulsen, Frank ; Weller, Michael ; Wick, Wolfgang
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Feb 2021 14:03

This publication is part of the DEAL contract with Springer.


Background Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL). Methods Neurocognitive functioning ...


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