TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-447181
DOI to cite this document:: 10.5283/epub.44718

Kunzelmann, Karl

; Cabrita, Ines ; Buchholz, Björn ; Schreiber, Rainer

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Date of publication of this fulltext: 05 Feb 2021 06:18

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Abstract

Polycystic kidney disease (PKD) leads to continuous decline of renal function by growth of renal cysts. Enhanced proliferation and transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and Ca2+-activated TMEM16A Cl- channels is thought to cause an increase in cyst volume. Recent work shows the pro-proliferative role of the Ca2+ activated Cl- channel ...