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Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes

URN to cite this document:
urn:nbn:de:bvb:355-epub-447193
DOI to cite this document:
10.5283/epub.44719
Sossalla, Samuel ; Pabel, Steffen ; Reetz, Florian ; Dybkova, Nataliya ; Shomroni, Orr ; Salinas, Gabriela ; Mustroph, Julian ; Hammer, Karin P. ; Hasenfuss, Gerd ; Hamdani, Nazha ; Maier, Lars S. ; Streckfuss-Bömeke, Katrin
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Feb 2021 06:37

This publication is part of the DEAL contract with Springer.


Abstract

The SGLT2 inhibitor empagliflozin improved cardiovascular outcomes in patients with diabetes. As the cardiac mechanisms remain elusive, we investigated the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner. IPSC from 3 donors, differentiated into pure iPSC-CM ...

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