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Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes

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Sossalla, Samuel ; Pabel, Steffen ; Reetz, Florian ; Dybkova, Nataliya ; Shomroni, Orr ; Salinas, Gabriela ; Mustroph, Julian ; Hammer, Karin P. ; Hasenfuss, Gerd ; Hamdani, Nazha ; Maier, Lars S. ; Streckfuss-Bömeke, Katrin
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Feb 2021 06:37

This publication is part of the DEAL contract with Springer.


The SGLT2 inhibitor empagliflozin improved cardiovascular outcomes in patients with diabetes. As the cardiac mechanisms remain elusive, we investigated the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM) in a blinded manner. IPSC from 3 donors, differentiated into pure iPSC-CM ...


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