A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2

URN to cite this document:

urn:nbn:de:bvb:355-epub-447391 Copy

DOI to cite this document:

10.5283/epub.44739 Copy

Cieplik, Fabian ; Gottsauner, Maximilian J. ; Michaelides, Ioannis ; Schmidt, Barbara ; Scholz, Konstantin J. ; Buchalla, Wolfgang ; Widbiller, Matthias ; Hitzenbichler, Florian ; Ettl, Tobias ; Reichert, Torsten E. ; Bohr, Christopher ; Vielsmeier, Veronika

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Date of publication of this fulltext: 05 Feb 2021 08:41

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Details

Item type:	Article
Journal or Publication Title:	Clinical Oral Investigations
Publisher:	Springer
Volume:	24
Page Range:	pp. 3707-3713
Date:	2 September 2020
Institutions:	Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie
Identification Number:	Value Type 10.1007/s00784-020-03549-1 DOI
Keywords:	SARS-CoV-2 . COVID-19 . Hydrogen peroxide . Mouthrinse . Gargle . Intraoral . Viral load
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Unknown
Created at the University of Regensburg:	Yes
Item ID:	44739

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Abstract

Objectives SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was to investigate ...

Abstract

Objectives
SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was to investigate the effects of a 1% hydrogen peroxide mouthrinse on reducing the intraoral SARS-CoV-2 load.

Methods
Twelve out of 98 initially screened hospitalized SARS-CoV-2-positive patients were included in this study. Intraoral viral load was determined by RT-PCR at baseline, whereupon patients had to gargle mouth and throat with 20 mL of 1% hydrogen peroxide for 30 s. After 30 min, a second examination of intraoral viral load was performed by RT-PCR. Furthermore, virus culture was performed for specimens exhibiting viral load of at least 103 RNA copies/mL at baseline.

Results
Ten out of the 12 initially included SARS-CoV-2-positive patients completed the study. The hydrogen peroxide mouthrinse led to no significant reduction of intraoral viral load. Replicating virus could only be determined from one baseline specimen.

Conclusion
A 1% hydrogen peroxide mouthrinse does not reduce the intraoral viral load in SARS-CoV-2-positive subjects. However, virus culture did not yield any indication on the effects of themouthrinse on the infectivity of the detected RNA copies.

Clinical relevance
The recommendation of a preprocedural mouthrinse with hydrogen peroxide before intraoral procedures is questionable and thus should not be supported any longer, but strict infection prevention regimens are of paramount importance.

Trial registration German Clinical Trials Register (ref. DRKS00022484)

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Metadata last modified: 05 Feb 2021 08:41

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