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An anisotropic nanocomposite hydrogel guides aligned orientation and enhances tenogenesis of human tendon stem/progenitor cells

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Docheva, Denitsa ; Xu, Yichi ; Yin, Heyong ; Chu, Jin ; Eglin, David ; Serra, Tiziano
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 01 Feb 2022 14:47


The uniform and aligned arrangement of tendon cells is a marker of tendon tissue morphology and the embodiment of its biological anisotropy. However, most of the hydrogels used for tendon tissue engineering do not present anisotropic structures. In this work, a magnetically-responsive nanocomposite hydrogel composed of collagen type I (COL I) and aligned iron oxide nanoparticles (IOPs) was ...


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