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Limited antimicrobial efficacy of oral care antiseptics in microcosm biofilms and phenotypic adaptation of bacteria upon repeated exposure

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Schwarz, Sophia R. ; Hirsch, Stefanie ; Hiergeist, Andreas ; Kirschneck, Christian ; Muehler, Denise ; Hiller, Karl-Anton ; Maisch, Tim ; Al-Ahmad, Ali ; Gessner, Andre ; Buchalla, Wolfgang ; Cieplik, Fabian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 05 Feb 2021 10:54

This publication is part of the DEAL contract with Springer.


Objectives The aims of this study were to investigate the antimicrobial efficacy of antiseptics in saliva-derived microcosm biofilms, and to examine phenotypic adaption of bacteria upon repeated exposure to sub-inhibitory antiseptic concentrations. Methods Saliva-derived biofilms were formed mimicking caries- or gingivitis-associated conditions, respectively. Microbial compositions were analyzed ...


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