Transport properties in CFTR−/− knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption

URN to cite this document:: urn:nbn:de:bvb:355-epub-448001
DOI to cite this document:: 10.5283/epub.44800

Benedetto, Roberta ; Centeio, Raquel ; Ousingsawat, Jiraporn ; Schreiber, Rainer ; Kunzelmann, Karl ;

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Date of publication of this fulltext: 08 Feb 2021 11:11

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Abstract

Previous analysis of CFTR-knockout (CFTR-/-) in piglets has provided important insights into the pathology of cystic fibrosis. However, controversies exist as to the true contribution of CFTR to the pH balance in airways and intestine. We therefore compared ion transport properties in newborn wild-type (CFTR+/+) and CFTR-knockout (CFTR-/- piglets). Tracheas of CFTR-/- piglets demonstrated typical ...