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Stress macht Zellen resistent gegen Folsäure-basierte Chemotherapeutika

URN to cite this document:
urn:nbn:de:bvb:355-epub-448065
DOI to cite this document:
10.5283/epub.44806
Ahrends, Robert ; Medenbach, Jan
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 08 Feb 2021 13:00

This publication is part of the DEAL contract with Springer.


Abstract

The unfolded protein response (UPR), a cellular stress response pathway, is broadly implicated in disease and resistance to therapy. The molecular mechanisms that drive stress-mediated chemoresistance are, however, only poorly understood. We have employed a multiomics approach to determine UPR-induced gene regulation, revealing the UPR regulon. We further observe metabolic rewiring upon stress ...

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