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A novel rabbit derived anti-HER2 antibody with pronounced therapeutic effectiveness on HER2-positive breast cancer cells in vitro and in humanized tumor mice (HTM)

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Wege, Anja K. ; Kirchhammer, Nicole ; Kazandjian, Linda Veronique ; Prassl, Sandra ; Brandt, Michael ; Piendl, Gerhard ; Ortmann, Olaf ; Fischer, Stephan ; Brockhoff, Gero
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Feb 2021 08:08


Background Antibody based cancer therapies have achieved convincing success rates combining enhanced tumor specificity and reduced side effects in patients. Trastuzumab that targets the human epidermal growth factor related receptor 2 (HER2) is one of the greatest success stories in this field. For decades, trastuzumab based treatment regimens are significantly improving the prognosis of ...


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