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Role and Regulation of Mechanotransductive HIF-1α Stabilisation in Periodontal Ligament Fibroblasts

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Kirschneck, Christian ; Thuy, Magdalena ; Leikam, Alexandra ; Memmert, Svenja ; Deschner, James ; Damanaki, Anna ; Spanier, Gerrit ; Proff, Peter ; Jantsch, Jonathan ; Schröder, Agnes
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Feb 2021 17:08


Orthodontic tooth movement (OTM) creates compressive and tensile strain in the periodontal ligament, causing circulation disorders. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) has been shown to be primarily stabilised by compression, but not hypoxia in periodontal ligament fibroblasts (PDLF) during mechanical strain, which are key regulators of OTM. This study aimed to elucidate the role of ...


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