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Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels

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Centeio, Raquel ; Ousingsawat, Jiraporn ; Schreiber, Rainer ; Kunzelmann, Karl
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Feb 2021 18:09


All vertebrate cells activate Cl- currents (I-Cl(,swell)) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1. However, apart from VRAC, the Ca2+-activated Cl- channel (CaCC) TMEM16A and the phospholipid scramblase and ion channel TMEM16F were suggested to contribute to cell swelling-activated whole-cell currents. Cell swelling ...


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