Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo

URN to cite this document:: urn:nbn:de:bvb:355-epub-449769
DOI to cite this document:: 10.5283/epub.44976

Cabrita, Ines ; Kraus, Andre ; Scholz, Julia Katharina ; Skoczynski, Kathrin ; Schreiber, Rainer ; Kunzelmann, Karl

; Buchholz, Björn

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Date of publication of this fulltext: 19 Feb 2021 09:48

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Abstract

In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1) are known to drive cyst enlargement. Here we demonstrate that loss of Pkd1 increased expression of TMEM16A and CFTR and Cl- ...