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Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease

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Haberl, Elisabeth M. ; Pohl, Rebekka ; Rein-Fischboeck, Lisa ; Höring, Marcus ; Krautbauer, Sabrina ; Liebisch, Gerhard ; Buechler, Christa
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 19 Feb 2021 12:42


Background Emerging data support a role for lipids in non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in humans. With experimental models such data can be challenged or validated. Mice fed a low-methionine, choline-deficient (LMCD) diet develop NASH and, when injected with diethylnitrosamine (DEN), HCC. Here, lipidomic analysis was used to elucidate whether the NASH and ...


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