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Disruption of Tfh:B Cell Interactions Prevents Antibody-Mediated Rejection in a Kidney Transplant Model in Rats: Impact of Calcineurin Inhibitor Dose

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Steines, Louisa ; Poth, Helen ; Schuster, Antonia ; Amann, Kerstin ; Banas, Bernhard ; Bergler, Tobias
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Jun 2021 08:59


We aimed to investigate the mechanisms of humoral immune activation in ABMR using a MHC-mismatched rat kidney transplant model. We applied low dose cyclosporine A (loCNI) to allow donor-specific antibody (DSA) formation and rejection and high dose cyclosporine A (hiCNI) for non-rejection. DSA and leukocyte subsets were measured by flow cytometry. Germinal centers (GC), T follicular helper cells ...


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