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Screening of Metal Complex – Amino Acid Side Chain Interactions by Potentiometric Titration

Kruppa, Michael, Frank, Daniel, Leffler-Schuster, Helga and König, Burkhard (2006) Screening of Metal Complex – Amino Acid Side Chain Interactions by Potentiometric Titration. Inorganica Chimica Acta 359 (4), pp. 1159-1168.

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Reversible coordination of amino acid side chains to metal complexes is widely used in protein purification (IMAC technique), but available data on affinity and selectivity of such binding processes are limited. We use potentiometric titration of a series of metal complexes with vacant coordination sites in the presence of molecules resembling amino acid side chain functionalities to screen for ...


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Item type:Article
Date:1 March 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
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Keywords:Potentiometric titration; Coordinative binding; IDA; NTA; Cyclen; Binding constant
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:45
Owner only: item control page


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