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Extracellular Citrate Fuels Cancer Cell Metabolism and Growth

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Haferkamp, Sebastian ; Drexler, Konstantin ; Federlin, Marianne ; Schlitt, Hans J. ; Berneburg, Mark ; Adamski, Jerzy ; Gaumann, Andreas ; Geissler, Edward K. ; Ganapathy, Vadivel ; Parkinson, E. Kenneth ; Mycielska, Maria E.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 26 Feb 2021 18:15


Cancer cells need excess energy and essential nutrients/metabolites not only to divide and proliferate but also to migrate and invade distant organs for metastasis. Fatty acid and cholesterol synthesis, considered a hallmark of cancer for anabolism and membrane biogenesis, requires citrate. We review here potential pathways in which citrate is synthesized and/or supplied to cancer cells and the ...


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