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Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors

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Klatt, Wybke ; Wallner, Susanne ; Brochhausen, Christoph ; Stolwijk, Judith A. ; Schreml, Stephan
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 23 Feb 2021 10:10


The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pH(e)). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with cancer cell proliferation, adhesion, ...


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