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MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1β, IL-18, and the inflammasome

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Stangl, Hubert Werner ; Krammetsvogl, Anita ; Lesiak, Martin ; Wolff, Christine ; Straub, Rainer H.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 23 Feb 2021 12:45


In experimental arthritis, glucocorticoid secretion is inadequate relative to inflammation. We hypothesized that IL-1 is a key factor for inadequate glucocorticoid secretion in arthritic rats. Collagen type II-induced arthritis (CIA) in DA rats was the model to study effects of IL-1 on adrenal function. In the CIA model, an increase of intraadrenal MHCII-positive cells was observed. ...


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