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Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model

URN to cite this document:
urn:nbn:de:bvb:355-epub-450897
DOI to cite this document:
10.5283/epub.45089
Borchers, Natascha S. ; Santos-Valente, Elisangela ; Toncheva, Antoaneta A. ; Wehkamp, Jan ; Franke, Andre ; Gaertner, Vincent D. ; Nordkild, Peter ; Genuneit, Jon ; Jensen, Benjamin A. H. ; Kabesch, Michael
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Date of publication of this fulltext: 11 Mar 2021 16:26


Abstract

Asthma and allergies are complex, chronic inflammatory diseases in which genetic and environmental factors are crucial. Protection against asthma and allergy development in the context of farming environment is established by early animal contact, unpasteurized milk consumption and gut microbiota maturation. The human β-defensin 2 (hBD-2) is a host defense peptide present almost exclusively in ...

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