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Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model

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Borchers, Natascha S. ; Santos-Valente, Elisangela ; Toncheva, Antoaneta A. ; Wehkamp, Jan ; Franke, Andre ; Gaertner, Vincent D. ; Nordkild, Peter ; Genuneit, Jon ; Jensen, Benjamin A. H. ; Kabesch, Michael
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 11 Mar 2021 16:26


Asthma and allergies are complex, chronic inflammatory diseases in which genetic and environmental factors are crucial. Protection against asthma and allergy development in the context of farming environment is established by early animal contact, unpasteurized milk consumption and gut microbiota maturation. The human beta-defensin 2 (hBD-2) is a host defense peptide present almost exclusively in ...


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