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A family affair: addressing the challenges of Factor H and the related proteins.

Poppelaars, Felix ; Goicoechea de Jorge, Elena ; Jongerius, Ilse ; Baeumner, Antje J. ; Steiner, Mark-Steven ; Józsi, Mihály ; Toonen, Erik J. M. ; Pauly, Diana


Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders. Recently, a family of proteins has been suggested to be of vital importance in conditions characterized by complement dysregulation: the human Factor H (FH) family. This group of proteins consists of FH, Factor H-like ...


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