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Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease—results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health

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Wolff, Daniel ; Herzberg, Philipp Y. ; Herrmann, Anne ; Pavletic, Steven Z. ; Heussner, Pia ; Mumm, Friederike ; Höfer, Christina ; Hilgendorf, Inken ; Hemmati, Philipp G. ; Holler, Ernst ; Greinix, Hildegard
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Mar 2021 06:38


Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Posttransplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL ...


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