Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease—results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health

URN to cite this document:

urn:nbn:de:bvb:355-epub-452271 Copy

DOI to cite this document:

10.5283/epub.45227 Copy

Wolff, Daniel ; Herzberg, Philipp Y. ; Herrmann, Anne ; Pavletic, Steven Z. ; Heussner, Pia ; Mumm, Friederike ; Höfer, Christina ; Hilgendorf, Inken ; Hemmati, Philipp G. ; Holler, Ernst ; Greinix, Hildegard

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Date of publication of this fulltext: 18 Mar 2021 06:38

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Details

Item type:	Article
Open Access Type:	DEAL (Springer)
Journal or Publication Title:	Bone Marrow Transplantation
Publisher:	Springer
Place of Publication:	LONDON
Volume:	56
Page Range:	pp. 243-256
Date:	31 July 2020
Institutions:	Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projects (Historical):	Else Kröner Fresenius Stiftung
Identification Number:	Value Type 10.1038/s41409-020-01017-8 UNSPECIFIED
Keywords:	HEMATOPOIETIC-CELL TRANSPLANTATION; LONG-TERM SURVIVORS; BONE-MARROW-TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; COMORBIDITY INDEX; CLINICAL-PRACTICE; ALLOGENEIC TRANSPLANTATION; INTERNATIONAL-BLOOD; FUNCTIONAL STATUS; APLASTIC-ANEMIA;
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	45227

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Abstract

Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Post-transplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL ...

Abstract

Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Post-transplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL within a multicenter trial, including 208 patients (pts) after alloHSCT, who were prospectively evaluated applying the FACT-BMT, the Human Activity Profile (HAP), the SF-36 v.2, PTMI and the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI). The most prevalent comorbidities were compensated arterial hypertension (28.4%), ambulatory infections (25.5%), iron overload (23%), mild renal function impairment (20%), and osteoporosis (13%). Applying the PTMI 13% of patients had no comorbidity, while 37.1% had 1-3 comorbidities, 27.4% had 4-6 comorbidities, and 13.5% had > 6 comorbidities. Chronic graft-versus-host disease (cGvHD) was significantly associated with the PTMI, while age and prior acute GvHD were not. In contrast, the HCT-CI was not associated with the presence of cGvHD. cGvHD was significantly associated with depression (r = 0.16), neurological disease (r = 0.21), osteoporosis (r = 0.18) and nonmelanoma skin cancer (r = 0.26). The PTMI demonstrated strong measurement properties and compared to the HCT-CI captured a wider range of comorbidities associated with cGvHD.

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Metadata last modified: 16 Jan 2025 15:00

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