CX3CL1 Overexpression Prevents the Formation of Lung Metastases in Trastuzumab-Treated MDA-MB-453-Based Humanized Tumor Mice (HTM)

URN to cite this document:: urn:nbn:de:bvb:355-epub-452835
DOI to cite this document:: 10.5283/epub.45283

Wege, Anja Kathrin

; Dreyer, Tobias F. ; Teoman, Attila ; Ortmann, Olaf

; Brockhoff, Gero ; Bronger, Holger

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Date of publication of this fulltext: 25 Jun 2021 15:10

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Abstract

CX3CL1 is a multifunctional chemokine that is involved in numerous biological processes, such as immune cell attraction and enhanced tumor immune cell interaction, but also in enhancing tumor cell proliferation and metastasis. The multifarious activity is partially determined by two CX3CL1 isoforms, a membrane-bound and a soluble version generated by proteolytic cleavage through proteases. Here, ...