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Classical isoforms of protein kinase C (PKC) and Akt regulate the osteogenic differentiation of human dental follicle cells via both β-catenin and NF-κB

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Morsczeck, Christian ; Pieles, Oliver ; Reichert, Torsten E.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Feb 2022 15:14


BackgroundHuman dental follicle cells (DFCs) are the precursor cells of the periodontium with a high potential for regenerative therapies of (alveolar) bone. However, the molecular mechanisms of osteogenic differentiation are inadequately understood. Classical isoforms of protein kinase C (PKC) are reported to inhibit osteogenesis of stem/precursor cells. This study evaluated the role of ...


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