We derive the two-loop evolution equation of the B-meson light-cone distribution amplitude which is the last missing element for the next-to-next-to-leading logarithmic resummation of QCD corrections to B decays in QCD factorization. We argue that the evolution kernel to all orders in perturbation theory can be written as a logarithm of the generator of special conformal transformations times the cusp anomalous dimension, up to a scheme-dependent overall constant. Up to this constant term, the evolution kernel to a given order in perturbation theory can be obtained from the calculation of special conformal anomaly at one order less.