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Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review

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Huber, D. ; Seitz, S. ; Kast, K. ; Emons, G. ; Ortmann, Olaf
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 28 Apr 2021 05:13

This publication is part of the DEAL contract with Springer.


Purpose BRCA mutation carriers have an increased risk of developing breast or ovarian cancer. Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is associated with a decrease in risk for tubal and ovarian cancer. Hormone replacement therapy (HRT) may increase breast, ovarian, and endometrial cancer risk in the general population. This review analyses the published data on HRT and risk of ...


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