| Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (5MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-456200
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.45620
Zusammenfassung
TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a secreted protein with protease activity that was demonstrated to enhance membrane expression of TMEM16A. Expression of CLCA1 is particularly enhanced in goblet cell metaplasia and is associated with various lung diseases. However, mice ...
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