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CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A

URN to cite this document:
urn:nbn:de:bvb:355-epub-456200
DOI to cite this document:
10.5283/epub.45620
Kunzelmann, Karl ; Centeio, Raquel ; Ousingsawat, Jiraporn ; Schreiber, Rainer
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jun 2021 15:17



Abstract

TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a secreted protein with protease activity that was demonstrated to enhance membrane expression of TMEM16A. Expression of CLCA1 is particularly enhanced in goblet cell metaplasia and is associated with various lung diseases. However, mice ...

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