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CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A

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Kunzelmann, Karl ; Centeio, Raquel ; Ousingsawat, Jiraporn ; Schreiber, Rainer
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jun 2021 15:17


TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a secreted protein with protease activity that was demonstrated to enhance membrane expression of TMEM16A. Expression of CLCA1 is particularly enhanced in goblet cell metaplasia and is associated with various lung diseases. However, mice ...


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