Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

URN to cite this document:: urn:nbn:de:bvb:355-epub-456536
DOI to cite this document:: 10.5283/epub.45653

Schreml, Stephan

; Ackermann, Kirsten ; Wallner, Susanne ; Brochhausen, Christoph

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jun 2021 16:05

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Abstract

The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pH(e)), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we ...