Decorin—An Antagonist of TGF-β in Astrocytes of the Optic Nerve

URN to cite this document:: urn:nbn:de:bvb:355-epub-459238
DOI to cite this document:: 10.5283/epub.45923

Fuchshofer, Rudolf

; Schneider, Magdalena ; Dillinger, Andrea E. ; Ohlmann, Andreas

; Iozzo, Renato V.

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Date of publication of this fulltext: 25 Jan 2022 15:16

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Abstract

During the pathogenesis of glaucoma, optic nerve (ON) axons become continuously damaged at the optic nerve head (ONH). This often is associated with reactive astrocytes and increased transforming growth factor (TGF-beta) 2 levels. In this study we tested the hypothesis if the presence or absence of decorin (DCN), a small leucine-rich proteoglycan and a natural inhibitor of several members of the ...