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Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans

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Kirschneck, Christian ; Silva-Sousa, Alice Correa ; Maranon-Vasquez, Guido Artemio ; Stuani, Maria Bernadete Sasso ; Proff, Peter ; Andrades, Kesly Mary Ribeiro ; Baratto-Filho, Flares ; Matsumoto, Mirian Aiko Nakane ; Paddenberg, Eva ; Küchler, Erika Calvano
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 10 Feb 2022 16:17


This study investigated, if genetic variants in BMP2, BMP4 and SMAD6 are associated with variations in the palatal rugae pattern in humans. Dental casts and genomic DNA from 75 patients were evaluated. Each patient was classified as follows: total amount of rugae; bilateral symmetry in the amount, length and shape of the palatal rugae; presence of secondary or fragmentary palatal rugae; presence ...


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