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Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement

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Kirschneck, Christian ; Straßmair, Nadine ; Cieplik, Fabian ; Paddenberg, Eva ; Jantsch, Jonathan ; Proff, Peter ; Schröder, Agnes
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Nov 2021 18:42


During orthodontic tooth movement, transcription factor hypoxia-inducible factor 1 alpha (HIF1 alpha) is stabilised in the periodontal ligament. While HIF1 alpha in periodontal ligament fibroblasts can be stabilised by mechanical compression, in macrophages pressure application alone is not sufficient to stabilise HIF1 alpha. The present study was conducted to investigate the role of myeloid HIF1 ...


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