Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-460605
DOI to cite this document:: 10.5283/epub.46060

Kunzelmann, Karl

; Centeio, Raquel ; Ousingsawat, Jiraporn

; Cabrita, Inês

; Schreiber, Rainer

; Talbi, Khaoula ; Benedetto, Roberta ; Doušová, Tereza

; Verbeken, Eric K. ; De Boeck, Kris ; Cohen, Isaac

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Date of publication of this fulltext: 25 Jan 2022 15:14

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Abstract

Activation of the Ca2+ activated Cl- channel TMEM16A is proposed as a treatment in inflammatory airway disease. It is assumed that activation of TMEM16A will induce electrolyte secretion, and thus reduce airway mucus plugging and improve mucociliary clearance. A benefit of activation of TMEM16A was shown in vitro and in studies in sheep, but others reported an increase in mucus production and ...