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Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease

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Kunzelmann, Karl ; Centeio, Raquel ; Ousingsawat, Jiraporn ; Cabrita, Inês ; Schreiber, Rainer ; Talbi, Khaoula ; Benedetto, Roberta ; Doušová, Tereza ; Verbeken, Eric K. ; De Boeck, Kris ; Cohen, Isaac
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jan 2022 15:14


Activation of the Ca2+ activated Cl- channel TMEM16A is proposed as a treatment in inflammatory airway disease. It is assumed that activation of TMEM16A will induce electrolyte secretion, and thus reduce airway mucus plugging and improve mucociliary clearance. A benefit of activation of TMEM16A was shown in vitro and in studies in sheep, but others reported an increase in mucus production and ...


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