RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues

URN to cite this document:: urn:nbn:de:bvb:355-epub-460638
DOI to cite this document:: 10.5283/epub.46063

Scheiter, Alexander ; Evert, Katja

; Reibenspies, Lucas ; Cigliano, Antonio

; Annweiler, Katharina ; Müller, Karolina

; Pöhmerer, Laura-Maria-Giovanna ; Xu, Hongwei ; Cui, Guofei ; Itzel, Timo ; Materna-Reichelt, Silvia ; Coluccio, Andrea ; Honarnejad, Kamran ; Teufel, Andreas ; Brochhausen, Christoph

; Dombrowski, Frank ; Chen, Xin ; Evert, Matthias ; Calvisi, Diego F. ; Utpatel, Kirsten

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Date of publication of this fulltext: 08 Mar 2022 18:16

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Abstract (German)

Aberrant activation of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR and Ras/mitogen-activated protein kinase (MAPK) pathways is a hallmark of hepatocarcinogenesis. In a subset of hepatocellular carcinomas (HCCs), PI3K/AKT/mTOR signaling dysregulation depends on phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations, while RAS/MAPK activation is partly ...