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RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues

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Scheiter, Alexander ; Evert, Katja ; Reibenspies, Lucas ; Cigliano, Antonio ; Annweiler, Katharina ; Müller, Karolina ; Pöhmerer, Laura-Maria-Giovanna ; Xu, Hongwei ; Cui, Guofei ; Itzel, Timo ; Materna-Reichelt, Silvia ; Coluccio, Andrea ; Honarnejad, Kamran ; Teufel, Andreas ; Brochhausen, Christoph ; Dombrowski, Frank ; Chen, Xin ; Evert, Matthias ; Calvisi, Diego F. ; Utpatel, Kirsten
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 08 Mar 2022 18:16

Abstract (German)

Aberrant activation of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR and Ras/mitogen-activated protein kinase (MAPK) pathways is a hallmark of hepatocarcinogenesis. In a subset of hepatocellular carcinomas (HCCs), PI3K/AKT/mTOR signaling dysregulation depends on phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations, while RAS/MAPK activation is partly ...


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