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Differential gene expression response of synovial fibroblasts from temporomandibular joints and knee joints to dynamic tensile stress

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Nazet, Ute ; Neubert, Patrick ; Schatz, Valentin ; Grässel, Susanne ; Proff, Peter ; Jantsch, Jonathan ; Schröder, Agnes ; Kirschneck, Christian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Jun 2021 06:01

This publication is part of the DEAL contract with Springer.


Purpose Apart from other risk factors, mechanical stress on joints can promote the development of osteoarthritis (OA), which can also affect the temporomandibular joint (TMJ), resulting in cartilage degeneration and synovitis. Synovial fibroblasts (SF) play an important role in upkeeping joint homeostasis and OA pathogenesis, but mechanical stress as a risk factor might act differently depending ...


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