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Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes

URN to cite this document:
urn:nbn:de:bvb:355-epub-460858
DOI to cite this document:
10.5283/epub.46085
Grässel, Susanne ; Eitner, Annett ; Bauer, Richard J. ; König, Matthias ; Johnstone, Brian ; Stöckl, Sabine
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 01 Oct 2021 17:41


Abstract

Osteoarthritis (OA) is a degenerative joint disease that not only causes cartilage loss but also structural damage in all joint tissues. Joints are innervated by alpha-calcitonin gene-related peptide (αCGRP) and substance P (SP)-positive sensory nerve fibers. Alteration of sensory joint innervation could be partly responsible for degenerative changes in joints that contribute to the development ...

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