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Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes

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Grässel, Susanne ; Eitner, Annett ; Bauer, Richard J. ; König, Matthias ; Johnstone, Brian ; Stöckl, Sabine
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 01 Oct 2021 17:41


Osteoarthritis (OA) is a degenerative joint disease that not only causes cartilage loss but also structural damage in all joint tissues. Joints are innervated by alpha-calcitonin gene-related peptide (alpha CGRP) and substance P (SP)-positive sensory nerve fibers. Alteration of sensory joint innervation could be partly responsible for degenerative changes in joints that contribute to the ...


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